Article

Received 04.11.2025

Revised 03.02.2026

Accepted 25.02.2026

Retrieved from Vol. 2, No. 1, 2026

Pages 28 -39

Zhilyaeva, O., Shishkina, V., Zolotareva, S., Ivanova, E., Tashmatova , N., Sakibaev, K., & Argynbaeva, A. (2026). Transplacental antibody perfusion in the development of the newborn passive immunity: A literature review. Journal of Human Biology and Clinical Medicine, 2(1), 28-39. https://doi.org/10.63621/jhbcm/1.2026.28

Transplacental antibody perfusion in the development of the newborn passive immunity: A literature review

Olga Zhilyaeva, Viktoria Shishkina, Svetlana Zolotareva, Elena Ivanova, Nazgul Tashmatova , Kyialbek Sakibaev, Akmaral Argynbaeva

Reducing infant mortality resulted from infections, particularly among premature infants, is a major public health concern. This fact emphasises the significance of transplacental transfer of maternal antibodies, including immunoglobulin G (IgG), to develop passive immunity and protect newborns from infections. The aim of this study was to summarise current findings on the mechanisms and factors affecting transplacental transfer of IgG and their role in the developing passive immunity in newborns. This review provided a systematic analysis of the scientific literature, including studies on the morphofunctional features of the placenta, the mechanisms of transplacental IgG perfusion, and their impact on fetal and neonatal immunological protection. The study supported the fact that IgG served a crucial function in the development of passive immunity in newborns, crossing the placental barrier and providing protection against infections in the early stages of life. As evidenced, the efficiency of transplacental IgG transfer varied depending on gestational age, with lower transfer rates in premature compared to full-term infants. The results demonstrated that different IgG subclasses (IgG1, IgG3, IgG4, and IgG2) were transferred across the placenta with varying efficiency, the fact associating with their affinity for the Fc receptor on the placenta. Infections and hypergammaglobulinemia in mothers were proved to affect transplacental IgG transfer, highlighting the need to monitor the infectious status of pregnant women to optimise neonatal protection. Maternal vaccination at specific stages of pregnancy was found to significantly increase IgG levels in the newborn’s blood, contributing to improved passive immunity and reducing the risk of infectious diseases in infants. The study results can be introduced into clinical practice to optimise vaccination strategies for pregnant women and develop personalised approaches for preventing infectious diseases in newborns, especially among premature neonates

placenta, transplacental transfer, immunoglobulin G, neonatal infections, immunological protection, placental barrier, gestational age
  1. Pomar L, Baud D. Special issue “Emerging virus infections in adverse pregnancy outcomes”. Viruses. 2022;14(2):285. DOI: 10.3390/v14020285
  2. Kravchenko EN, Kuklina LV, Shevlyukova TP. Intrauterine infection: Risk factors and diagnostic challenges during pregnancy. Obst Gynecol: News Opin Train. 2023;11(4):35–44. DOI: 10.33029/2303-9698-2023-11-4-35-44
  3. Wang W, Sung N, Gilman-Sachs A, Kwak-Kim J. T helper (Th) cell profiles in pregnancy and recurrent pregnancy losses: Th1/Th2/Th9/Th17/Th22/Tfh cells. Front Immunol. 2020;11:2025. DOI: 10.3389/fimmu.2020.02025
  4. Piccinni MP, Raghupathy R, Saito S, Szekeres-Bartho J. Cytokines, hormones and cellular regulatory mechanisms favoring successful reproduction. Front Immunol. 2021;12:717808. DOI: 10.3389/fimmu.2021.717808
  5. Yockey LJ, Lucas C, Iwasaki A. Contributions of maternal and fetal antiviral immunity in congenital disease. Science. 2020;368(6491):eaz1960. DOI: 10.1126/science.aaz1960
  6. Rumyantsev AG. The role of innate fetal immunity factors, microbiome, and maternal infections in the formation of perinatal pathology in newborns. Pediatria. 2025;104(1):8–14. DOI: 10.24110/0031-403X-2025-104-1-8-14
  7. Ciobanu AM, Dumitru AE, Gica N, Botezatu R, Peltecu G, Panaitescu AM. Benefits and risks of IgG transplacental transfer. Diagnostics. 2020;10(8):583. DOI: 10.3390/diagnostics10080583
  8. Shuid AN, Jayusman PA, Shuid N, Ismail J, Kamal Nor N, Mohamed IN. Association between viral infections and risk of autistic disorder: an overview. Int J Environ Res Public Health. 2021;18(6):2817. DOI: 10.3390/ijerph18062817
  9. Shook LL, Batorsky RE, De Guzman RM, McCrea LT, Brigida SM, Horng JE, et al. Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment. J Neuroinflammation. 2024;21(1):163. DOI: 10.1186/s12974-024-03157-w
  10. Galkina DE, Makarenko TA, Okladnikov DV. Immunological aspects of normal and pathological pregnancy. Bull Russ Acad Med Sci. 2022;77(1):13–24. DOI: 10.15690/vramn1507
  11. Ding J, Maxwell A, Adzibolosu N, Hu A, You Y, Liao AH, et al. Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon-stimulated genes signaling during pregnancy. Immunol Rev. 2022;308(1):9–24. DOI: 10.1111/imr.13077
  12. Napodano C, Marino MP, Stefanile A, Pocino K, Scatena R, Gulli F, et al. Immunological role of IgG subclasses. Immunol Investig. 2020;50:427–44. DOI: 10.1080/08820139.2020.1775643
  13. Kozlov VA, Savchenko AA, Simbirtsev AS, Kudlai DA, Anisimova EN, Borisov AG. Immunopathological syndromes associated with adaptive immunity. Cytokine Inflamm. 2024;21(4):186–95. DOI: 10.17816/CI679042
  14. Abbas AK, Lichtman AH, Pillai S. Basic immunology: Functions and disorders of the immune system. 7th ed. Philadelphia, PA: Elsevier Health Sciences; 2023. 352 P.
  15. Chernyak BA, Vorzheva II. Pathology of the respiratory system in primary immunodeficiencies. In: Respiratory medicine: A guide in 5 volumes. 3rd ed. Moscow: Pulmomedia LLC; 2024. P. 386–421. DOI: 10.18093/978-5-6052509-1-3-2024-4-386-421
  16. Pitcher-Wilmott RW, Hindocha P, Wood CB. The placental transfer of IgG subclasses in human pregnancy. Clin Exp Immunol. 1980;41(2):303–8.
  17. Jennewein MF, Goldfarb I, Dolatshahi S, Cosgrove C, Noelette FJ, Krykbaeva M, et al. Fc glycan-mediated regulation of placental antibody transfer. Cell. 2019;178(1):202–15. DOI: 10.1016/j.cell.2019.05.044
  18. Twisselmann N, Bartsch YC, Pagel J, Wieg C, Hartz A, Ehlers M, et al. IgG Fc glycosylation patterns of preterm infants differ with gestational age. Front Immunol. 2019;9:3166. DOI: 10.3389/fimmu.2018.03166
  19. Borghi S, Bournazos S, Thulin NK, Li C, Gajewski A, Sherwood RW, et al. FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies. Proc Natl Acad Sci U S A. 2020;117(23):12943–51. DOI: 10.1073/pnas.2004325117
  20. Knudsen Sand KM, Gruber MM, Sandlie I, Mathiesen L, Andersen JT, Wadsack C. Contribution of the ex vivo placental perfusion model in understanding transplacental immunoglobulin G transfer. Placenta. 2022;127:77–87. DOI: 10.1016/j.placenta.2022.07.019
  21. Lozano NA, Lozano A, Marini V, Saranz RJ, Blumberg RS, Baker K, et al. Expression of FcRn receptor in placental tissue and its relationship with IgG levels in term and preterm newborns. Am J Reprod Immunol. 2018;80(3):e12972. DOI: 10.1111/aji.12972
  22. Ozdemir SA, Ozer EA, Kose S, Ilhan O, Ozturk C, Sutcuoglu S. Reference values of serum IgG and IgM levels in preterm and term newborns. J Matern Fetal Neonatal Med. 2016;29(6):472–6. DOI: 10.3109/14767058.2015.1027680
  23. Pereira RA, Oliveira de Almeida V, Vidori L, Colvero MO, Amantéa SL. Immunoglobulin G and subclasses placental transfer in fetuses and preterm newborns: A systematic review. J Perinatol. 2023;43(1):3–9. DOI: 10.1038/s41372-022-01528-w
  24. Bokonbaeva SD, Urmatova BK, Zeivald SV, Asanbekova ZhA. Immune status and inflammatory mediators in premature newborns with respiratory distress syndrome. Sci Rev Med Sci. 2025;(2):16–21. DOI: 10.17513/srms.1436
  25. van Duuren IC, van Hengel ORJ, Penders J, Duijts L, Smits HH, Tramper-Stranders GA. The developing immune system in preterm born infants: From contributor to potential solution for respiratory tract infections and wheezing. Allergy. 2024;79(11):2924–42. DOI: 10.1111/all.16342
  26. Palmeira A, Sousa E, Köseler A, Sabirli R, Gören T, Türkçüer İ, et al. Correction: Palmeira et al. Preliminary virtual screening studies to identify GRP78 inhibitors which may interfere with SARS-CoV-2 infection. Pharmaceuticals (Basel). 2024;17(4):411. DOI: 10.3390/ph17040411
  27. Akbulut H, Çelik İ, Çelik A, Akbulut A, Ayar A. Placental transfer of total IgG and IgG subclasses in a Turkish population living in eastern Anatolia. Nobel Med. 2012;8(2):59–64.
  28. Omowale SS, Gary-Webb TL, Wallace ML, Wallace JM, Rauktis ME, Eack SM, et al. Stress during pregnancy: An ecological momentary assessment of stressors among black and white women with implications for maternal health. Womens Health (Lond). 2022;18:17455057221126808. DOI: 10.1177/17455057221126808
  29. Ohlsson A, Lacy JB. Intravenous immunoglobulin for suspected or proven infection in neonates. Cochrane Database Syst Rev. 2020;2020(1):CD001239. DOI: 10.1002/14651858.CD001239.pub6
  30. Balanovskaya LN, Loginova YA. Features of newborns’ immunity in different countries. In: Interdisciplinary immunology: Prospects for development: Materials of the II all-Russian scientific and practical conference of students and young scientists. Kirov: Kirov State Medical University; 2025. P. 20–1.
  31. Clements T, Rice TF, Vamvakas G, Barnett S, Barnes M, Donaldson B, et al. Update on transplacental transfer of IgG subclasses: Impact of maternal and fetal factors. Front Immunol. 2020;11:1920. DOI: 10.3389/fimmu.2020.01920
  32. Okoko BJ, Wesumperuma LH, Ota MOC, Pinder M, Banya W, Gomez SF, et al. The influence of placental malaria infection and maternal hypergammaglobulinemia on transplacental transfer of antibodies and IgG subclasses in a rural West African population. J Infect Dis. 2001;184(5):627–33. DOI: 10.1086/322808
  33. Volkova EN, Ippolitova LI. Markers of the cellular immune response (TREC and KREC) in newborns of different gestational age. Verkhnevolzhsky Med J. 2025;24(1):35–8.
  34. Lu H, Shen H, Mao L, Mussap M, Song L. A ferroptosis-related ceRNA network for investigating the molecular mechanisms and the treatment of neonatal hypoxic-ischemic encephalopathy. Transl Pediatr. 2024;13(1):119–36. DOI: 10.21037/tp-23-596
  35. Atyeo C, DeRiso EA, Davis C, Bordt EA, De Guzman RM, Shook LL, et al. COVID-19 mRNA vaccines drive differential antibody Fc-functional profiles in pregnant, lactating, and nonpregnant women. Sci Transl Med. 2021;13(617):eabi8631. DOI: 10.1126/scitranslmed.abi8631
  36. Stach SCL, Brizot ML, Liao AW, Palmeira P, Francisco RPV, Carneiro-Sampaio MMS, et al. Placental transfer of IgG antibodies specific to Klebsiella and Pseudomonas LPS and to group B Streptococcus in twin pregnancies. Scand J Immunol. 2015;81(2):135­41. DOI: 10.1111/sji.12258
  37. Satlikov RK, Masharipova IYu. Management tactics of pregnancy and treatment with anti-Rh immunoglobulin of pregnant women with negative Rh factor. Internauka. 2021;(5–1):46–8.
  38. Kozlyakova OV, Klimovich OV, Goldinberg BM, Kamalova OV, Rak MA, Avtukhova TE, et al. The first results of immunological screening of pregnant women. Is there a need for specific prevention of Rh-immunization in the presence of another type of anti-erythrocyte antibodies? Reprod Health East Eur. 2021;11(2):177–84. DOI: 10.34883/PI.2021.11.2.004
  39. Potapova VE, Prishchepenko OA, Lysenko IM. Modern concepts of the pathogenesis of hemolytic disease of newborns. Prot Mother Child. 2020;(2):95–101.
  40. Zhong Z, Haltalli M, Holder B, Rice T, Donaldson B, O’Driscoll M, et al. The impact of timing of maternal influenza immunization on infant antibody levels at birth. Clin Exp Immunol. 2019;195(2):139–52. DOI: 10.1111/cei.13234
  41. Efimkova EB, Dulaeva EV, Kravtsova ON. SARS-CoV-2 vaccination of pregnant women during the 2020-2023 pandemic: Implications for obstetric and perinatal outcomes. Doctor Ru. 2025;24(5):68–73. DOI: 10.31550/1727-2378-2025-24-5-68-73
  42. Kostinov MP, Markelova EV, Svitich OA, Polishchuk VB. Immune mechanisms of SARS-CoV-2 and potential drugs in the prevention and treatment of COVID-19. Pulmonologiya. 2020;30(5):700–8. DOI: 10.18093/0869-0189-2020-30-5-700-708
  43. Krasnopolsky VI, Petrukhin VA, Zarochentseva NV, Belaya YM, Bocharova II, Vodovatova VA, et al. The features of the course of pregnancy and its outcomes in women vaccinated against papillomavirus infection. Obstet Gynecol. 2020;1:146–54. DOI: 10.18565/aig.2020.1.146-15